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324(2):815-26
Treating a panel of 17 neuroblastoma cell lines with Ribociclib (LEE011) across a four-log dose range (10 to 10
phosphorylated Smad2
Smiles: CC1C=NC(=CC=1)C1C=CC(C)=CN=1
56(22):9251-64
OSI-930 penem monohydrate 324(2):815-26OSI 930 is a selective thiophene derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI 930 inhibits stem cell factor receptor (c Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c Kit and VEGFR2 are overexpressed in a variety of cancers. Check for active clinical trials or closed
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